Fever in pregnancy linked to autism
Women who run a high temperature during gestation may double risk of having an autistic child
Researchers found out that women having fever while pregnancy and not treating it are twice as likely to have a child with autism than mothers who do not report any untreated fever. Scientists assumed that there might be a link between infectuous diseases during gestation and a heightened risk of children having autism spectrum disorder, which could not be confirmed by the new study in the upcoming Journal of Autism and Developmental Disorders. According to Paul Patterson, a developmental neurologist at Caltech, this was the largest and most careful study that had been done on the topic of fever and influenza in autism development.
Fever in gestation was also associated with a more than doubled risk of
developmental delays, report the researchers. Gestation, therefore, can be regarded as a critical period for fetal development. This was partly due to the inflammatory proteins (cytokines) that occur during fever, because they could easily pass through the placenta and might cause harm in so far as to alter the brain development of the fetus at a crucial time, study coauthor Ousseny Zerbo, an epidemiologist at the Kaiser Permanente Northern California Division of Research in Oakland, reports.
Moreover, the heat of the fever can cause neurons to fire more and damage the fetal brain growth.
Although this was an improved study compared to previous work on fever and autism, Patterson points out that the data are based on the mothers' memories of events that occured years earlier and that they are subject to recall bias. However, there is still a large interest in understanding why and how children might be affected by autism spectrum disorder.
For reference see: http://www.sciencenews.org/view/generic/id/341059/title/Fever_in_pregnancy_linked_to_autism
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Researchers have [T/Asp] found out that women who suffer from [T/Asp,Gr,E,foc,coh,M] fever while pregnant [WF,M] and do [Gr,foc,coh,M]not treat [T/Asp] it are twice as likely to have a child with autism as [W,Gr] mothers who do not report any untreated fever. Scientists assume [T/Asp] that there might be a link between infectuous diseases during gestation and a heightened risk of children having autism spectrum disorder, but this [E,coh,M] could not be confirmed by the new study in the upcoming Journal of Autism and Developmental Disorders. According to Paul Patterson, a developmental neurologist at Caltech, this was the largest and most careful study that had been done on the topic of fever and influenza in autism development.
AntwortenLöschenFever in gestation was also associated with a more than doubled risk of developmental delays, report the researchers. Gestation, therefore, can be regarded as a critical period for fetal development. This is [T/Asp] partly due to the inflammatory proteins (cytokines) that form [W,M,coh] during fever, which can [T/Asp.E,M,coh]easily pass through the placenta and [m,coh]cause harm by altering [E,M,coh] the brain development of the fetus at a crucial time, study coauthor Ousseny Zerbo, an epidemiologist at the Kaiser Permanente Northern California Division of Research in Oakland, reports. [no new ¶] Moreover, the heat of the fever can cause neurons to fire more and damage the fetal brain growth.
Although this was an improved study compared to previous work on fever and autism, Patterson points out that the data are based on the mothers' memories of events that had [T/Asp] occurred [Sp] years earlier and that the mothers [foc] are subject to recall bias. However, there is still a large interest in understanding why and how children might be affected by autism spectrum disorder.